Antibody Diversity Wu and Kabat 1970: a Transforming View Of
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Kabat Database and its applications: 30 years after the first variability plot
The Kabat Database was initially started in 1970 to determine the combining site of antibodies based on the available amino acid sequences at that time. Bence Jones proteins, mostly from human, were aligned, using the now-known Kabat numbering system, and a quantitative measure, variability, was calculated for every position. Three peaks, at positions 24-34, 50-56 and 89-97, were identified and...
متن کاملProtein Sequence and Structure Analysis of Antibody Variable Domains
Porter (1959) first proposed the four-chain model for antibodies consisting of two light chains and two heavy chains, linked by disulphide bonds. The structure of antibodies has been reviewed in detail by a number of authors (Alzari et al. 1988; Padlan 1994; Searle et al. 1994), while the structural basis of antibody/antigen interactions has also been reviewed extensively (Padlan 1977; Mariuzza...
متن کاملKabat Database and its applications: future directions
The Kabat Database was initially started in 1970 to determine the combining site of antibodies based on the available amino acid sequences. The precise delineation of complementarity determining regions (CDR) of both light and heavy chains provides the first example of how properly aligned sequences can be used to derive structural and functional information of biological macromolecules. This k...
متن کاملVIR.II: a new interface with the antibody sequences in the Kabat database.
The Kabat database is the source of information par excellence on antibody sequences. In 1995, we developed an interface with the Kabat database, called VIR. VIR has been very useful in conducting studies aiming to find structure-function relationships in antibodies. Here we report a new version adapted to the World Wide Web, called VIR.II. VIR.II allows searches by type of chain (V(H) or V(L))...
متن کاملAn Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and Their Implications for Antibody Complementarity
In an attempt to account for antibody specificity and complementarity in terms of structure, human kappa-, human lambda-, and mouse kappa-Bence Jones proteins and light chains are considered as a single population and the variable and constant regions are compared using the sequence data available. Statistical criteria are used in evaluating each position in the sequence as to whether it is ess...
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تاریخ انتشار 2008